Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology.
Identifieur interne : 000099 ( Main/Exploration ); précédent : 000098; suivant : 000100Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology.
Auteurs : Marie Von Lilienfeld-Toal [Allemagne] ; Annemarie Berger [Allemagne] ; Maximilian Christopeit [Allemagne] ; Marcus Hentrich [Allemagne] ; Claus Peter Heussel [Allemagne] ; Jana Kalkreuth [Allemagne] ; Michael Klein [Allemagne] ; Matthias Kochanek [Allemagne] ; Olaf Penack [Allemagne] ; Elke Hauf [Allemagne] ; Christina Rieger [Allemagne] ; Gerda Silling [Allemagne] ; Maria Vehreschild [Allemagne] ; Thomas Weber [Allemagne] ; Hans-Heinrich Wolf [Allemagne] ; Nicola Lehners [Allemagne] ; Enrico Schalk [Allemagne] ; Karin Mayer [Allemagne]Source :
- European journal of cancer (Oxford, England : 1990) [ 1879-0852 ] ; 2016.
Descripteurs français
- KwdFr :
- Allemagne, Antiviraux (usage thérapeutique), Cytosine (analogues et dérivés), Cytosine (usage thérapeutique), Facteurs immunologiques (usage thérapeutique), Grippe humaine (), Grippe humaine (diagnostic), Grippe humaine (épidémiologie), Humains, Hygiène des mains, Immunoglobulines par voie veineuse (usage thérapeutique), Infections communautaires (), Infections communautaires (diagnostic), Infections communautaires (épidémiologie), Infections de l'appareil respiratoire (), Infections de l'appareil respiratoire (diagnostic), Infections de l'appareil respiratoire (épidémiologie), Infections humaines à adénovirus (), Infections humaines à adénovirus (diagnostic), Infections humaines à adénovirus (épidémiologie), Infections à Paramyxoviridae (), Infections à Paramyxoviridae (diagnostic), Infections à Paramyxoviridae (épidémiologie), Infections à virus respiratoire syncytial (), Infections à virus respiratoire syncytial (diagnostic), Infections à virus respiratoire syncytial (épidémiologie), Isolement du patient, Maladies virales (), Maladies virales (diagnostic), Maladies virales (épidémiologie), Masques, Metapneumovirus, Oncologie médicale, Oséltamivir (usage thérapeutique), Phosphonates (usage thérapeutique), Pneumopathie virale (), Pneumopathie virale (diagnostic), Pneumopathie virale (épidémiologie), Poumon (imagerie diagnostique), Ribavirine (usage thérapeutique), Sialidase (antagonistes et inhibiteurs), Techniques d'amplification d'acides nucléiques, Tomodensitométrie, Tumeurs (épidémiologie).
- MESH :
- analogues et dérivés : Cytosine.
- antagonistes et inhibiteurs : Sialidase.
- diagnostic : Grippe humaine, Infections communautaires, Infections de l'appareil respiratoire, Infections humaines à adénovirus, Infections à Paramyxoviridae, Infections à virus respiratoire syncytial, Maladies virales, Pneumopathie virale.
- imagerie diagnostique : Poumon.
- usage thérapeutique : Antiviraux, Cytosine, Facteurs immunologiques, Immunoglobulines par voie veineuse, Oséltamivir, Phosphonates, Ribavirine.
- épidémiologie : Grippe humaine, Infections communautaires, Infections de l'appareil respiratoire, Infections humaines à adénovirus, Infections à Paramyxoviridae, Infections à virus respiratoire syncytial, Maladies virales, Pneumopathie virale, Tumeurs.
- Allemagne, Grippe humaine, Humains, Hygiène des mains, Infections communautaires, Infections de l'appareil respiratoire, Infections humaines à adénovirus, Infections à Paramyxoviridae, Infections à virus respiratoire syncytial, Isolement du patient, Maladies virales, Masques, Metapneumovirus, Oncologie médicale, Pneumopathie virale, Techniques d'amplification d'acides nucléiques, Tomodensitométrie.
English descriptors
- KwdEn :
- Adenovirus Infections, Human (diagnosis), Adenovirus Infections, Human (epidemiology), Adenovirus Infections, Human (therapy), Antiviral Agents (therapeutic use), Cidofovir, Community-Acquired Infections (diagnosis), Community-Acquired Infections (epidemiology), Community-Acquired Infections (therapy), Cytosine (analogs & derivatives), Cytosine (therapeutic use), Germany, Hand Hygiene, Humans, Immunoglobulins, Intravenous (therapeutic use), Immunologic Factors (therapeutic use), Influenza, Human (diagnosis), Influenza, Human (epidemiology), Influenza, Human (therapy), Lung (diagnostic imaging), Masks, Medical Oncology, Metapneumovirus, Neoplasms (epidemiology), Neuraminidase (antagonists & inhibitors), Nucleic Acid Amplification Techniques, Organophosphonates (therapeutic use), Oseltamivir (therapeutic use), Paramyxoviridae Infections (diagnosis), Paramyxoviridae Infections (epidemiology), Paramyxoviridae Infections (therapy), Patient Isolation, Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (therapy), Respiratory Syncytial Virus Infections (diagnosis), Respiratory Syncytial Virus Infections (epidemiology), Respiratory Syncytial Virus Infections (therapy), Respiratory Tract Infections (diagnosis), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (therapy), Ribavirin (therapeutic use), Tomography, X-Ray Computed, Virus Diseases (diagnosis), Virus Diseases (epidemiology), Virus Diseases (therapy).
- MESH :
- chemical , analogs & derivatives : Cytosine.
- chemical , antagonists & inhibitors : Neuraminidase.
- chemical , therapeutic use : Antiviral Agents, Cytosine, Immunoglobulins, Intravenous, Immunologic Factors, Organophosphonates, Oseltamivir, Ribavirin.
- diagnosis : Adenovirus Infections, Human, Community-Acquired Infections, Influenza, Human, Paramyxoviridae Infections, Pneumonia, Viral, Respiratory Syncytial Virus Infections, Respiratory Tract Infections, Virus Diseases.
- diagnostic imaging : Lung.
- epidemiology : Adenovirus Infections, Human, Community-Acquired Infections, Influenza, Human, Neoplasms, Paramyxoviridae Infections, Pneumonia, Viral, Respiratory Syncytial Virus Infections, Respiratory Tract Infections, Virus Diseases.
- therapy : Adenovirus Infections, Human, Community-Acquired Infections, Influenza, Human, Paramyxoviridae Infections, Pneumonia, Viral, Respiratory Syncytial Virus Infections, Respiratory Tract Infections, Virus Diseases.
- chemical : Cidofovir, Germany, Hand Hygiene, Humans, Masks, Medical Oncology, Metapneumovirus, Nucleic Acid Amplification Techniques, Patient Isolation, Tomography, X-Ray Computed.
Abstract
BACKGROUND
Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.
METHODS
A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus.
RESULTS
CRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis.
CONCLUSIONS
CRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome.
DOI: 10.1016/j.ejca.2016.08.015
PubMed: 27681877
Affiliations:
- Allemagne
- Bade-Wurtemberg, Bavière, Berlin, District de Cologne, District de Darmstadt, District de Haute-Bavière, District de Karlsruhe, District de Münster, Hambourg, Hesse (Land), Rhénanie-du-Nord-Westphalie, Saxe-Anhalt
- Aix-la-Chapelle, Berlin, Bonn, Francfort-sur-le-Main, Hambourg, Heidelberg, Magdebourg, Munich, Recklinghausen (Ruhr)
- Université Johann Wolfgang Goethe de Francfort-sur-le-Main, Université Louis-et-Maximilien de Munich
Links toward previous steps (curation, corpus...)
Le document en format XML
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sortKey="Hentrich, Marcus" sort="Hentrich, Marcus" uniqKey="Hentrich M" first="Marcus" last="Hentrich">Marcus Hentrich</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, Red Cross Hospital, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, Red Cross Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Heussel, Claus Peter" sort="Heussel, Claus Peter" uniqKey="Heussel C" first="Claus Peter" last="Heussel">Claus Peter Heussel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kalkreuth, Jana" sort="Kalkreuth, Jana" uniqKey="Kalkreuth J" first="Jana" last="Kalkreuth">Jana Kalkreuth</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Medical Oncology, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Michael" sort="Klein, Michael" uniqKey="Klein M" first="Michael" last="Klein">Michael Klein</name><affiliation wicri:level="3"><nlm:affiliation>Department I of Internal Medicine, Prosper-Hospital, Recklinghausen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Prosper-Hospital, Recklinghausen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Recklinghausen (Ruhr)</settlement></placeName></affiliation></author><author><name sortKey="Kochanek, Matthias" sort="Kochanek, Matthias" uniqKey="Kochanek M" first="Matthias" last="Kochanek">Matthias Kochanek</name><affiliation wicri:level="1"><nlm:affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Penack, Olaf" sort="Penack, Olaf" uniqKey="Penack O" first="Olaf" last="Penack">Olaf Penack</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Tumorimmunology, Charité Campus Virchow, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Oncology and Tumorimmunology, Charité Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hauf, Elke" sort="Hauf, Elke" uniqKey="Hauf E" first="Elke" last="Hauf">Elke Hauf</name><affiliation wicri:level="3"><nlm:affiliation>Department III of Internal Medicine, The University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department III of Internal Medicine, The University Hospital Klinikum rechts der Isar, Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Rieger, Christina" sort="Rieger, Christina" uniqKey="Rieger C" first="Christina" last="Rieger">Christina Rieger</name><affiliation wicri:level="4"><nlm:affiliation>Lehrpraxis der Ludwig-Maximilians-Universität München, Germering, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Lehrpraxis der Ludwig-Maximilians-Universität München, Germering</wicri:regionArea><wicri:noRegion>Germering</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Silling, Gerda" sort="Silling, Gerda" uniqKey="Silling G" first="Gerda" last="Silling">Gerda Silling</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Vehreschild, Maria" sort="Vehreschild, Maria" uniqKey="Vehreschild M" first="Maria" last="Vehreschild">Maria Vehreschild</name><affiliation wicri:level="1"><nlm:affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Thomas" sort="Weber, Thomas" uniqKey="Weber T" first="Thomas" last="Weber">Thomas Weber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, Hans Heinrich" sort="Wolf, Hans Heinrich" uniqKey="Wolf H" first="Hans-Heinrich" last="Wolf">Hans-Heinrich Wolf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Lehners, Nicola" sort="Lehners, Nicola" uniqKey="Lehners N" first="Nicola" last="Lehners">Nicola Lehners</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, University Hospital of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, University Hospital of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schalk, Enrico" sort="Schalk, Enrico" uniqKey="Schalk E" first="Enrico" last="Schalk">Enrico Schalk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Mayer, Karin" sort="Mayer, Karin" uniqKey="Mayer K" first="Karin" last="Mayer">Karin Mayer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27681877</idno><idno type="pmid">27681877</idno><idno type="doi">10.1016/j.ejca.2016.08.015</idno><idno type="wicri:Area/Main/Corpus">000076</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000076</idno><idno type="wicri:Area/Main/Curation">000076</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000076</idno><idno type="wicri:Area/Main/Exploration">000076</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology.</title><author><name sortKey="Von Lilienfeld Toal, Marie" sort="Von Lilienfeld Toal, Marie" uniqKey="Von Lilienfeld Toal M" first="Marie" last="Von Lilienfeld-Toal">Marie Von Lilienfeld-Toal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany; Centre for Sepsis Control and Care (CSCC), University Hospital Jena, Germany; Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institut, Jena, Germany. Electronic address: Marie.von_Lilienfeld-Toal@med.uni-jena.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany; Centre for Sepsis Control and Care (CSCC), University Hospital Jena, Germany; Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institut, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt</wicri:regionArea><placeName><settlement type="city">Francfort-sur-le-Main</settlement><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region></placeName><orgName type="university">Université Johann Wolfgang Goethe de Francfort-sur-le-Main</orgName></affiliation></author><author><name sortKey="Christopeit, Maximilian" sort="Christopeit, Maximilian" uniqKey="Christopeit M" first="Maximilian" last="Christopeit">Maximilian Christopeit</name><affiliation wicri:level="3"><nlm:affiliation>Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Hentrich, Marcus" sort="Hentrich, Marcus" uniqKey="Hentrich M" first="Marcus" last="Hentrich">Marcus Hentrich</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, Red Cross Hospital, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, Red Cross Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Heussel, Claus Peter" sort="Heussel, Claus Peter" uniqKey="Heussel C" first="Claus Peter" last="Heussel">Claus Peter Heussel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kalkreuth, Jana" sort="Kalkreuth, Jana" uniqKey="Kalkreuth J" first="Jana" last="Kalkreuth">Jana Kalkreuth</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Medical Oncology, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Michael" sort="Klein, Michael" uniqKey="Klein M" first="Michael" last="Klein">Michael Klein</name><affiliation wicri:level="3"><nlm:affiliation>Department I of Internal Medicine, Prosper-Hospital, Recklinghausen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Prosper-Hospital, Recklinghausen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Recklinghausen (Ruhr)</settlement></placeName></affiliation></author><author><name sortKey="Kochanek, Matthias" sort="Kochanek, Matthias" uniqKey="Kochanek M" first="Matthias" last="Kochanek">Matthias Kochanek</name><affiliation wicri:level="1"><nlm:affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Penack, Olaf" sort="Penack, Olaf" uniqKey="Penack O" first="Olaf" last="Penack">Olaf Penack</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Tumorimmunology, Charité Campus Virchow, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Oncology and Tumorimmunology, Charité Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hauf, Elke" sort="Hauf, Elke" uniqKey="Hauf E" first="Elke" last="Hauf">Elke Hauf</name><affiliation wicri:level="3"><nlm:affiliation>Department III of Internal Medicine, The University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department III of Internal Medicine, The University Hospital Klinikum rechts der Isar, Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Rieger, Christina" sort="Rieger, Christina" uniqKey="Rieger C" first="Christina" last="Rieger">Christina Rieger</name><affiliation wicri:level="4"><nlm:affiliation>Lehrpraxis der Ludwig-Maximilians-Universität München, Germering, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Lehrpraxis der Ludwig-Maximilians-Universität München, Germering</wicri:regionArea><wicri:noRegion>Germering</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Silling, Gerda" sort="Silling, Gerda" uniqKey="Silling G" first="Gerda" last="Silling">Gerda Silling</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Vehreschild, Maria" sort="Vehreschild, Maria" uniqKey="Vehreschild M" first="Maria" last="Vehreschild">Maria Vehreschild</name><affiliation wicri:level="1"><nlm:affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Thomas" sort="Weber, Thomas" uniqKey="Weber T" first="Thomas" last="Weber">Thomas Weber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, Hans Heinrich" sort="Wolf, Hans Heinrich" uniqKey="Wolf H" first="Hans-Heinrich" last="Wolf">Hans-Heinrich Wolf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Lehners, Nicola" sort="Lehners, Nicola" uniqKey="Lehners N" first="Nicola" last="Lehners">Nicola Lehners</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, University Hospital of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, University Hospital of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schalk, Enrico" sort="Schalk, Enrico" uniqKey="Schalk E" first="Enrico" last="Schalk">Enrico Schalk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Mayer, Karin" sort="Mayer, Karin" uniqKey="Mayer K" first="Karin" last="Mayer">Karin Mayer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></analytic><series><title level="j">European journal of cancer (Oxford, England : 1990)</title><idno type="eISSN">1879-0852</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenovirus Infections, Human (diagnosis)</term><term>Adenovirus Infections, Human (epidemiology)</term><term>Adenovirus Infections, Human (therapy)</term><term>Antiviral Agents (therapeutic use)</term><term>Cidofovir</term><term>Community-Acquired Infections (diagnosis)</term><term>Community-Acquired Infections (epidemiology)</term><term>Community-Acquired Infections (therapy)</term><term>Cytosine (analogs & derivatives)</term><term>Cytosine (therapeutic use)</term><term>Germany</term><term>Hand Hygiene</term><term>Humans</term><term>Immunoglobulins, Intravenous (therapeutic use)</term><term>Immunologic Factors (therapeutic use)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (therapy)</term><term>Lung (diagnostic imaging)</term><term>Masks</term><term>Medical Oncology</term><term>Metapneumovirus</term><term>Neoplasms (epidemiology)</term><term>Neuraminidase (antagonists & inhibitors)</term><term>Nucleic Acid Amplification Techniques</term><term>Organophosphonates (therapeutic use)</term><term>Oseltamivir (therapeutic use)</term><term>Paramyxoviridae Infections (diagnosis)</term><term>Paramyxoviridae Infections (epidemiology)</term><term>Paramyxoviridae Infections (therapy)</term><term>Patient Isolation</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (therapy)</term><term>Respiratory Syncytial Virus Infections (diagnosis)</term><term>Respiratory Syncytial Virus Infections (epidemiology)</term><term>Respiratory Syncytial Virus Infections (therapy)</term><term>Respiratory Tract Infections (diagnosis)</term><term>Respiratory Tract Infections (epidemiology)</term><term>Respiratory Tract Infections (therapy)</term><term>Ribavirin (therapeutic use)</term><term>Tomography, X-Ray Computed</term><term>Virus Diseases (diagnosis)</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne</term><term>Antiviraux (usage thérapeutique)</term><term>Cytosine (analogues et dérivés)</term><term>Cytosine (usage thérapeutique)</term><term>Facteurs immunologiques (usage thérapeutique)</term><term>Grippe humaine ()</term><term>Grippe humaine (diagnostic)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Hygiène des mains</term><term>Immunoglobulines par voie veineuse (usage thérapeutique)</term><term>Infections communautaires ()</term><term>Infections communautaires (diagnostic)</term><term>Infections communautaires (épidémiologie)</term><term>Infections de l'appareil respiratoire ()</term><term>Infections de l'appareil respiratoire (diagnostic)</term><term>Infections de l'appareil respiratoire (épidémiologie)</term><term>Infections humaines à adénovirus ()</term><term>Infections humaines à adénovirus (diagnostic)</term><term>Infections humaines à adénovirus (épidémiologie)</term><term>Infections à Paramyxoviridae ()</term><term>Infections à Paramyxoviridae (diagnostic)</term><term>Infections à Paramyxoviridae (épidémiologie)</term><term>Infections à virus respiratoire syncytial ()</term><term>Infections à virus respiratoire syncytial (diagnostic)</term><term>Infections à virus respiratoire syncytial (épidémiologie)</term><term>Isolement du patient</term><term>Maladies virales ()</term><term>Maladies virales (diagnostic)</term><term>Maladies virales (épidémiologie)</term><term>Masques</term><term>Metapneumovirus</term><term>Oncologie médicale</term><term>Oséltamivir (usage thérapeutique)</term><term>Phosphonates (usage thérapeutique)</term><term>Pneumopathie virale ()</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (épidémiologie)</term><term>Poumon (imagerie diagnostique)</term><term>Ribavirine (usage thérapeutique)</term><term>Sialidase (antagonistes et inhibiteurs)</term><term>Techniques d'amplification d'acides nucléiques</term><term>Tomodensitométrie</term><term>Tumeurs (épidémiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cytosine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Cytosine</term><term>Immunoglobulins, Intravenous</term><term>Immunologic Factors</term><term>Organophosphonates</term><term>Oseltamivir</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Cytosine</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Sialidase</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Adenovirus Infections, Human</term><term>Community-Acquired Infections</term><term>Influenza, Human</term><term>Paramyxoviridae Infections</term><term>Pneumonia, Viral</term><term>Respiratory Syncytial Virus Infections</term><term>Respiratory Tract Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term><term>Infections communautaires</term><term>Infections de l'appareil respiratoire</term><term>Infections humaines à adénovirus</term><term>Infections à Paramyxoviridae</term><term>Infections à virus respiratoire syncytial</term><term>Maladies virales</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Adenovirus Infections, Human</term><term>Community-Acquired Infections</term><term>Influenza, Human</term><term>Neoplasms</term><term>Paramyxoviridae Infections</term><term>Pneumonia, Viral</term><term>Respiratory Syncytial Virus Infections</term><term>Respiratory Tract Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Adenovirus Infections, Human</term><term>Community-Acquired Infections</term><term>Influenza, Human</term><term>Paramyxoviridae Infections</term><term>Pneumonia, Viral</term><term>Respiratory Syncytial Virus Infections</term><term>Respiratory Tract Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Cytosine</term><term>Facteurs immunologiques</term><term>Immunoglobulines par voie veineuse</term><term>Oséltamivir</term><term>Phosphonates</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections communautaires</term><term>Infections de l'appareil respiratoire</term><term>Infections humaines à adénovirus</term><term>Infections à Paramyxoviridae</term><term>Infections à virus respiratoire syncytial</term><term>Maladies virales</term><term>Pneumopathie virale</term><term>Tumeurs</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Cidofovir</term><term>Germany</term><term>Hand Hygiene</term><term>Humans</term><term>Masks</term><term>Medical Oncology</term><term>Metapneumovirus</term><term>Nucleic Acid Amplification Techniques</term><term>Patient Isolation</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allemagne</term><term>Grippe humaine</term><term>Humains</term><term>Hygiène des mains</term><term>Infections communautaires</term><term>Infections de l'appareil respiratoire</term><term>Infections humaines à adénovirus</term><term>Infections à Paramyxoviridae</term><term>Infections à virus respiratoire syncytial</term><term>Isolement du patient</term><term>Maladies virales</term><term>Masques</term><term>Metapneumovirus</term><term>Oncologie médicale</term><term>Pneumopathie virale</term><term>Techniques d'amplification d'acides nucléiques</term><term>Tomodensitométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>CRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>CRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27681877</PMID><DateCompleted><Year>2017</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0852</ISSN><JournalIssue CitedMedium="Internet"><Volume>67</Volume><PubDate><Year>2016</Year><Month>11</Month></PubDate></JournalIssue><Title>European journal of cancer (Oxford, England : 1990)</Title><ISOAbbreviation>Eur. J. Cancer</ISOAbbreviation></Journal><ArticleTitle>Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology.</ArticleTitle><Pagination><MedlinePgn>200-212</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0959-8049(16)32388-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejca.2016.08.015</ELocationID><Abstract><AbstractText Label="BACKGROUND">Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.</AbstractText><AbstractText Label="METHODS">A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus.</AbstractText><AbstractText Label="RESULTS">CRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis.</AbstractText><AbstractText Label="CONCLUSIONS">CRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome.</AbstractText><CopyrightInformation>Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>von Lilienfeld-Toal</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany; Centre for Sepsis Control and Care (CSCC), University Hospital Jena, Germany; Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institut, Jena, Germany. Electronic address: Marie.von_Lilienfeld-Toal@med.uni-jena.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>Annemarie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christopeit</LastName><ForeName>Maximilian</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hentrich</LastName><ForeName>Marcus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Haematology and Oncology, Red Cross Hospital, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heussel</LastName><ForeName>Claus Peter</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kalkreuth</LastName><ForeName>Jana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department I of Internal Medicine, Prosper-Hospital, Recklinghausen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kochanek</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Penack</LastName><ForeName>Olaf</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Hematology, Oncology and Tumorimmunology, Charité Campus Virchow, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauf</LastName><ForeName>Elke</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department III of Internal Medicine, The University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rieger</LastName><ForeName>Christina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Lehrpraxis der Ludwig-Maximilians-Universität München, Germering, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silling</LastName><ForeName>Gerda</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vehreschild</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weber</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolf</LastName><ForeName>Hans-Heinrich</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>Department of Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lehners</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Haematology and Oncology, University Hospital of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schalk</LastName><ForeName>Enrico</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayer</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Haematology and Oncology, University Hospital Bonn, 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(Land)</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe-Anhalt</li></region><settlement><li>Aix-la-Chapelle</li><li>Berlin</li><li>Bonn</li><li>Francfort-sur-le-Main</li><li>Hambourg</li><li>Heidelberg</li><li>Magdebourg</li><li>Munich</li><li>Recklinghausen (Ruhr)</li></settlement><orgName><li>Université Johann Wolfgang Goethe de Francfort-sur-le-Main</li><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Von Lilienfeld Toal, Marie" sort="Von Lilienfeld Toal, Marie" uniqKey="Von Lilienfeld Toal M" first="Marie" last="Von Lilienfeld-Toal">Marie Von Lilienfeld-Toal</name></noRegion><name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name><name sortKey="Christopeit, Maximilian" sort="Christopeit, Maximilian" uniqKey="Christopeit M" first="Maximilian" last="Christopeit">Maximilian Christopeit</name><name sortKey="Hauf, Elke" sort="Hauf, Elke" 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sort="Penack, Olaf" uniqKey="Penack O" first="Olaf" last="Penack">Olaf Penack</name><name sortKey="Rieger, Christina" sort="Rieger, Christina" uniqKey="Rieger C" first="Christina" last="Rieger">Christina Rieger</name><name sortKey="Schalk, Enrico" sort="Schalk, Enrico" uniqKey="Schalk E" first="Enrico" last="Schalk">Enrico Schalk</name><name sortKey="Silling, Gerda" sort="Silling, Gerda" uniqKey="Silling G" first="Gerda" last="Silling">Gerda Silling</name><name sortKey="Vehreschild, Maria" sort="Vehreschild, Maria" uniqKey="Vehreschild M" first="Maria" last="Vehreschild">Maria Vehreschild</name><name sortKey="Weber, Thomas" sort="Weber, Thomas" uniqKey="Weber T" first="Thomas" last="Weber">Thomas Weber</name><name sortKey="Wolf, Hans Heinrich" sort="Wolf, Hans Heinrich" uniqKey="Wolf H" first="Hans-Heinrich" last="Wolf">Hans-Heinrich Wolf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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